Core Paramedic Medications
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Core paramedic medications, standard adult emergency dosages, and administration routes.
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- Epinephrine (Cardiac Arrest)
- 1 mg (1:10,000) IV/IO push every 3-5 minutes
- Epinephrine (Anaphylaxis)
- 0.3-0.5 mg (1:1,000) IM into the anterolateral thigh every 5-15 minutes
- Amiodarone (Cardiac Arrest - Pulseless VT/VF)
- First dose: 300 mg IV/IO push; Second dose: 150 mg IV/IO push
- Amiodarone (Stable Wide-Complex Tachycardia)
- 150 mg IV/IO infused over 10 minutes
- Lidocaine (Cardiac Arrest - Pulseless VT/VF)
- First dose: 1.0-1.5 mg/kg IV/IO; Repeat dose: 0.5-0.75 mg/kg every 5-10 minutes (max 3 mg/kg)
- Atropine Sulfate (Symptomatic Bradycardia)
- 1 mg IV/IO push every 3-5 minutes (maximum total dose 3 mg)
- Adenosine (Stable SVT)
- Initial dose: 6 mg rapid IV push followed by immediate 20 mL saline flush; Second dose: 12 mg if needed
- Diltiazem (Cardizem - Rapid Atrial Fibrillation/Flutter)
- 0.25 mg/kg IV slow push over 2 minutes; repeat at 0.35 mg/kg after 15 minutes if needed
- Aspirin (Acute Coronary Syndrome)
- 162-324 mg chewable PO (non-enteric coated)
- Nitroglycerin (Angina / ACS)
- 0.4 mg sublingual (tablet or spray) every 5 minutes (max 3 doses, systolic BP > 90-100 mmHg)
- Morphine Sulfate (Severe Ischemic Pain)
- 2-4 mg slow IV push every 5-15 minutes titrated to pain and blood pressure
- Fentanyl (Acute Pain Management)
- 50-100 mcg (or 1 mcg/kg) slow IV/IO/IM/IN push, titrated every 5-10 minutes
- Naloxone (Opioid Overdose)
- 0.4-2 mg IV/IO/IM/SC or 2-4 mg IN, titrated to restore adequate respirations
- Albuterol (Bronchospasm / Asthma)
- 2.5 mg in 3 mL normal saline via nebulizer over 5-15 minutes
- Ipratropium Bromide (Atrovent - Bronchospasm)
- 0.5 mg in 2.5 mL normal saline via nebulizer (often combined with albuterol)
- Methylprednisolone (Solu-Medrol - Severe Asthma/COPD)
- 125 mg slow IV/IO push over 2 minutes
- Dexamethasone (Decadron - Airway Inflammation)
- 8-16 mg IV, IO, or IM push
- Magnesium Sulfate (Torsades de Pointes)
- 1-2 g diluted in 10 mL D5W/NS IV/IO push over 1-2 minutes
- Magnesium Sulfate (Severe Refractory Asthma)
- 2 g diluted in 100 mL IV piggyback infused over 15-20 minutes
- Magnesium Sulfate (Eclampsia / Severe Pre-eclampsia)
- 4-6 g IV loading dose in 100 mL over 15-20 minutes, followed by 1-2 g/hr continuous infusion
- Dextrose 10% (D10W - Hypoglycemia)
- 125-250 mL (12.5-25 g) IV/IO rapid infusion, re-evaluating blood glucose
- Dextrose 50% (D50W - Hypoglycemia)
- 25 g (50 mL of 50% solution) slow IV/IO push
- Glucagon (Hypoglycemia without IV access)
- 1 mg IM or SC (reconstituted powder)
- Glucagon (Beta-Blocker Overdose)
- 3-5 mg slow IV push over 2-3 minutes, followed by an infusion of 2-5 mg/hr
- Oral Glucose (Hypoglycemia - Conscious Adult)
- 15-25 g orally/buccal (1 tube of gel)
- Midazolam (Versed - Active Seizure)
- 5-10 mg IM/IN, or 2-5 mg slow IV/IO push titrated to seizure cessation
- Lorazepam (Ativan - Active Seizure)
- 2-4 mg slow IV/IO/IM push over 2 minutes
- Diazepam (Valium - Active Seizure)
- 5-10 mg slow IV push over 2 minutes (or 0.2 mg/kg rectally)
- Ondansetron (Zofran - Nausea and Vomiting)
- 4 mg slow IV/IO push over 2-5 minutes or 4 mg ODT (oral dissolving tablet)
- Promethazine (Phenergan - Severe Nausea)
- 12.5-25 mg deep IM or slow IV diluted in 10-20 mL normal saline (administered with caution)
- Metoclopramide (Reglan - Nausea / Migraine)
- 10 mg slow IV push over 1-2 minutes or IM
- Diphenhydramine (Benadryl - Allergic Reaction)
- 25-50 mg deep IM or slow IV/IO push
- Sodium Bicarbonate (Severe Acidosis / TCA Overdose)
- 1 mEq/kg IV/IO rapid bolus, repeat at 0.5 mEq/kg every 10 minutes as indicated by QRS width
- Calcium Chloride (Hyperkalemia / Calcium Channel Blocker Toxicity)
- 500-1000 mg (5-10 mL of 10% solution) slow IV/IO push over 5-10 minutes
- Calcium Gluconate (Hyperkalemia)
- 1-2 g (10-20 mL of 10% solution) slow IV/IO push over 5-10 minutes
- Norepinephrine (Levophed - Cardiogenic/Septic Shock)
- 2-12 mcg/min IV/IO continuous infusion titrated to mean arterial pressure ≥ 65 mmHg
- Dopamine (Cardiogenic Shock / Symptomatic Bradycardia)
- 5-20 mcg/kg/min IV/IO continuous infusion, titrated to patient hemodynamics
- Epinephrine (Push-Dose Epinephrine - Hypotension)
- 5-20 mcg (0.5-2 mL of 10 mcg/mL solution) IV/IO every 2-5 minutes
- Ketamine (Dissociative Induction / RSI)
- 1.5-2 mg/kg IV/IO push or 3-4 mg/kg IM
- Ketamine (Analgesia)
- 0.1-0.3 mg/kg IV/IO slow infusion over 10-15 minutes or 0.5 mg/kg IN
- Ketamine (Excited Delirium / Chemical Restraint)
- 4-5 mg/kg IM or 1-2 mg/kg IV/IO
- Etomidate (Amidate - RSI Sedation Induction)
- 0.3 mg/kg IV/IO rapid push
- Propofol (RSI / Post-Intubation Sedation)
- Induction: 1.5-2.5 mg/kg IV push; Maintenance: 5-50 mcg/kg/min infusion
- Succinylcholine (Anectine - RSI Paralytic)
- 1.5-2.0 mg/kg rapid IV/IO push
- Rocuronium (Zemuron - RSI Paralytic)
- 1.0-1.2 mg/kg rapid IV/IO push
- Vecuronium (Norcuron - RSI Paralytic / Post-Intubation)
- 0.1 mg/kg IV/IO push
- Tranexamic Acid (TXA - Severe Hemorrhagic Shock)
- 1 g mixed in 100 mL NS or D5W infused IV/IO over 10 minutes within 3 hours of injury
- Hydralazine (Hypertensive Crisis in Pregnancy)
- 5-10 mg slow IV push over 2 minutes; repeat in 20 minutes if needed
- Labetalol (Hypertensive Emergency / Severe Pre-eclampsia)
- 10-20 mg slow IV push over 2 minutes; may double every 10 minutes (max 300 mg)
- Oxytocin (Pitocin - Postpartum Hemorrhage)
- 10 units IM, or 10-40 units diluted in 1,000 mL crystalloid infused IV at 200-500 mL/hr
- Activated Charcoal (Acute Toxic Ingestion)
- 1 g/kg (typically 50-100 g) PO or via nasogastric tube within 1 hour of ingestion
- Hydroxocobalamin (Cyanokit - Cyanide Poisoning)
- 5 g IV infusion over 15 minutes; a second 5 g dose may be infused over 15 minutes to 2 hours
- Atropine Sulfate (Organophosphate / Nerve Agent Poisoning)
- 2-4 mg IV/IM every 3-5 minutes until tracheobronchial secretions clear
- Pralidoxime (2-PAM - Organophosphate Poisoning)
- 1-2 g IV/IO mixed in 100 mL saline infused over 15-30 minutes, or 1-2 g IM
- Flumazenil (Romazicon - Benzodiazepine Reversal)
- 0.2 mg slow IV push over 30 seconds; repeat with 0.3-0.5 mg every minute up to 1 mg total (use with caution)
- Haloperidol (Haldol - Acute Psychosis / Agitation)
- 2.5-10 mg IM or slow IV push
- Droperidol (Inapsine - Severe Agitation / Nausea)
- 2.5-5 mg IM or slow IV push
- Acetaminophen (Tylenol - Mild-Moderate Pain / Fever)
- 650-1000 mg PO or 1000 mg IV infusion over 15 minutes
- Ketorolac (Toradol - Moderate-Severe Musculoskeletal/Renal Colic Pain)
- 15 mg IV push or 30 mg IM (single dose)
- Nitrous Oxide (50:50 Entonox/Nitronox - Acute Pain)
- Self-administered by the patient via demand valve mask or mouthpiece